Testosterone Plus Finasteride Prevents Bone Loss without Prostate Growth in a Rodent Spinal Cord Injury Model.
RatSpinal cord injuryContusionSprague-DawleyMalen = 43 rats in total; per-group numbers not statedTestosterone-enanthate intramuscular; finasteride subcutaneousTestosterone-enanthate 7.0 mg/week; finasteride 5 mg/kg/day
Model: Severe 250 kdyne contusion spinal cord injury; sham animals received laminectomy only
Testosterone-enanthate prevented the injury-induced loss of levator ani/bulbocavernosus muscle mass, normalised cancellous and cortical bone turnover and maintained cancellous bone mass at sham level, but produced prostate enlargement, whereas co-administered finasteride preserved these musculoskel…
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