FTY720 promotes pulmonary fibrosis when administered during the remodelling phase following a bleomycin-induced lung injury.
MouseChemical/toxinC57BL/6Male0.1 mg/kgDelivered either during the inflammatory phase or during the remodelling phase…
Model: Bleomycin-induced acute lung injury and fibrosis
FTY720 given during the inflammatory phase decreased fibrosis by 60% and lung stiffness by 28%, whereas the same dose given during the remodelling phase increased fibrosis 2.1-fold and lung stiffness 1.7-fold, associated with increased connective tissue growth factor but not vascular leakage. Timin…
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