Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart.
RatChemical/toxinSprague-DawleyMalen = Experiment 1: 32 rats, 4 groups of 8; experiment 2: 16 rats…Intravenous via tail vein5 mg/kg/day (pharmacodynamic study); single 5.0 mg/kg dose…First dose immediately after doxorubicin injection in the pharmacodynamic study…
Model: Doxorubicin-induced acute cardiotoxicity (single intraperitoneal dose of 20 mg/kg doxorubicin); pharmacokinetic experiments used a single intravenous 5 mg/kg doxorubicin dose
Scutellarin co-treatment reduced LDH activity from 4057.8 to 2595.9, malondialdehyde from 2.083 to 1.380 nmol/mg protein and cardiac troponin T from 0.1695 to 0.0222 ng/mL, and raised LVEF from 47.75 to 76.70% and LVFS from 20.66 to 40.28%, with markedly reduced cardiac histological damage. It lowe…
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