Kindlin-1 contributes to EGF-induced re-epithelialization in skin wound healing.
MouseWoundBalb/cn = 60 mice randomised into 10 groups, 6 animals per grouptopical2,000 IU/mL, one spray per woundapplied after wounding; exact start time not stated
Model: Two 5 mm full thickness dorsal punch wounds through skin and panniculus carnosus per mouse
Topical EGF improved the healing rate from 72.73 to 90.54 per cent at day 14 with a more rapid and prolonged rise in Kindlin-1 expression; Kindlin-1 knockdown in vitro reduced activated integrin beta1 by approximately 36 to 58 per cent, migration by approximately 35 per cent and proliferation by ap…
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