Biologic
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Neoplasms, Breast
Enrolment: 455 · Results not recorded
Non Small Cell Lung Cancer
Enrolment: 1093 · Results not recorded
Foot Ulcer, Diabetic · Epidermal Growth Factor
Enrolment: 304 · Results not recorded
Neoplasms
Enrolment: 160 · Results not recorded
Oral Mucositis
Enrolment: 138 · Results not recorded
Breast Cancer · Gastric Cancer · Gastroesophageal Junction Adenocarcinoma
Enrolment: 0 · Results not recorded
Metastatic Lung Non-Small Cell Carcinoma · Recurrent Lung Non-Small Cell Carcinoma
Enrolment: 138 · Results not recorded
Periodontitis
Enrolment: 30 · Results not recorded
Skin Graft Scar · Split-Thickness Skin Graft (STSG)
Enrolment: 10 · Results not recorded
5 studies reported at therapy level; 5 evidence entries itemised.
Model: Gastric ulcer induced by submucosal injection of 0.03 ml of 20% acetic acid; delayed healing produced by daily indomethacin 1 mg/kg subcutaneously for 4 weeks
hEGF at 100 and 300 micrograms/kg significantly accelerated both natural and indomethacin-delayed healing of acetic acid gastric ulcers, and inhibited basal and histamine-stimulated acid secretion, suggesting healing is mediated largely by antisecretory activity.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: T9 laminectomy with moderate contusion spinal cord injury, 150 kdyn with no dwell time using an Infinite Horizon impactor
EGF preserved blood-spinal cord barrier integrity and improved locomotor recovery through PI3K/Akt/Rac1 dependent maintenance of junction proteins.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: High-dose whole-body irradiation (12 and 13 Gy, 60Co, 0.59-0.57 Gy/min) causing gastrointestinal damage
BMT and EGF each increased survival after 13 Gy and attenuated radiation-induced gastrointestinal atrophy while increasing regeneration in the first week, with the combination most effective; neither improved early cytopenia.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Hepatic warm ischaemia and reperfusion by occlusion of the blood supply to the median and left hepatic lobes
VEGFR1 tyrosine kinase knockout mice showed delayed liver repair, sustained sinusoidal damage and reduced pro-angiogenic factor expression. Treatment with epidermal growth factor attenuated hepatocellular and sinusoidal injury in these mice.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Two 5 mm full thickness dorsal punch wounds through skin and panniculus carnosus per mouse
Topical EGF improved the healing rate from 72.73 to 90.54 per cent at day 14 with a more rapid and prolonged rise in Kindlin-1 expression; Kindlin-1 knockdown in vitro reduced activated integrin beta1 by approximately 36 to 58 per cent, migration by approximately 35 per cent and proliferation by ap…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
