Effects of luteolin and luteolin-morphine co-administration on acute and chronic pain and sciatic nerve ligated-induced neuropathy in mice.
MouseOtheralbinon = 14 groups of 7 miceintraperitonealLuteolin 2.5, 5 and 10 mg/kg body weight; morphine 9 mg/kg…
Model: Sciatic nerve ligation-induced neuropathy, with hot plate and formalin tests for acute and chronic pain
Luteolin at 5 and 10 mg/kg significantly reduced neuropathic pain versus negative control (P < 0.05), comparable with imipramine (P < 0.001), and co-administration with morphine 1 mg/kg potentiated morphine antinociception (P < 0.001).
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.