Olfactory Dysfunction After COVID-19: Conventional Therapy Versus co-ultraPEALut
Anosmia · COVID-19 · Hyposmia · Parosmia
Enrolment: 200 · Results not recorded
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Nutraceutical · No ChEMBL mechanism-of-action table record. Natural flavone (natural product flag true), max_phase 2.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Anosmia · COVID-19 · Hyposmia · Parosmia
Enrolment: 200 · Results not recorded
Autism Spectrum Disorders
Enrolment: 50 · Results not recorded
Tongue Neoplasms · Carcinoma
Enrolment: 4 · Results not recorded
Memory
Enrolment: 44 · Results not recorded
Acute Ischemic Stroke
Enrolment: 60 · Results not recorded
Metabolic Syndrome
Enrolment: 100 · Results not recorded
Allergic Rhinoconjunctivitis
Enrolment: 150 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Moderate controlled cortical impact over the left frontoparietal cortex (1.0 mm tip, 1.0 mm impact depth, 6 m/s velocity, 100 ms dwell time)
Traumatic brain injury significantly raised soluble (monomeric) amyloid-beta, activated GSK-3, phospho-tau, TNF-alpha and IL-1 beta at 3 days. Luteolin pre-treatment significantly abolished these increases. Insoluble amyloid-beta was not significantly increased. Total luteolin reached approximately…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: 30 minutes of superior mesenteric artery occlusion followed by 2 hours of reperfusion after laparotomy; sham animals had laparotomy only
Luteolin significantly reduced histological injury (p=0.037) and tissue total oxidant status (p=0.005) compared with untreated ischaemia-reperfusion, while total antioxidant capacity was unchanged (p>0.05).
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Sciatic nerve ligation-induced neuropathy, with hot plate and formalin tests for acute and chronic pain
Luteolin at 5 and 10 mg/kg significantly reduced neuropathic pain versus negative control (P < 0.05), comparable with imipramine (P < 0.001), and co-administration with morphine 1 mg/kg potentiated morphine antinociception (P < 0.001).
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.