Protective Effect of Thymoquinone Against Morphine Injuries to Kidneys of Mice.
MouseChemical/toxinBALB/cmalen = 48 mice, 6 per groupintraperitoneal4.5 mg/kg, 9 mg/kg and 18 mg/kgadministered concurrently with morphine
Model: Morphine-induced kidney injury over 20 consecutive days
Thymoquinone co-administration significantly increased kidney weight and glomerular number and diameter and reduced blood urea nitrogen, serum creatinine and serum nitric oxide compared with morphine alone (P < .05).
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