Effects of delayed NSAID administration after experimental eccentric contraction injury - A cellular and proteomics study.
Model: Eccentric contraction-induced injury of the tibialis anterior muscle; electrical stimulation at 10-12 V, 100-150 Hz for 400 ms via needle electrodes near the right peroneal nerve with the foot rotated distally 78 degrees beginning 200 ms after nerve stimulation, repeated every 30 s for 50 repetitions; only animals with a greater than 40% fall in maximal mean isometric torque were included
Delayed ketorolac inhibited several muscle regeneration processes and down-regulated multiple cytoprotective proteins that inhibit the intrinsic pathway of programmed cell death. This was associated with increased caspase activity in injured muscle and was independent of any effect on macrophage in…
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