ACUVAIL (ketorolac tromethamine ophthalmic solution) 0.45% in post-PRK corneal wound healing
Post-PRK corneal wound healing
Enrolment: 10 · Results not recorded
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Drug · Cyclooxygenase inhibitor (INHIBITOR, direct interaction); parent ChEMBL entry CHEMBL469 carries a black box warning and a withdrawn flag
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Post-PRK corneal wound healing
Enrolment: 10 · Results not recorded
Probable Migraine · Migraine With Aura · Migraine Without Aura
Enrolment: 56 · Results not recorded
Pain, Postoperative · Otitis Media
Enrolment: 150 · Results not recorded
Sickle Cell Disease · Sickle Cell Crisis
Enrolment: 102 · Results not recorded
Acute Renal Colic
Enrolment: 171 · Results not recorded
Cesarean Section
Enrolment: 118 · Results not recorded
Retinopathy of Prematurity
Enrolment: 14 · Results not recorded
Healthy Volunteers
Enrolment: 15 · Results not recorded
Post-operative Pain
Enrolment: 48 · Results not recorded
Macular Edema, Cystoid
Enrolment: 98 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Eccentric contraction-induced injury of the tibialis anterior muscle; electrical stimulation at 10-12 V, 100-150 Hz for 400 ms via needle electrodes near the right peroneal nerve with the foot rotated distally 78 degrees beginning 200 ms after nerve stimulation, repeated every 30 s for 50 repetitions; only animals with a greater than 40% fall in maximal mean isometric torque were included
Delayed ketorolac inhibited several muscle regeneration processes and down-regulated multiple cytoprotective proteins that inhibit the intrinsic pathway of programmed cell death. This was associated with increased caspase activity in injured muscle and was independent of any effect on macrophage in…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.