Faecal microbiota transplantation protects against radiation-induced toxicity
MouseRadiationC57BL/6Jmale and femalen = n = 18 per group for survival and body weight; n = 12 per g…Oral gavage (antibiotics given in drinking water)Donor stool diluted with 1 ml saline per 0.1 g stool, steep…Started after 6.5 Gy total body irradiation; antibiotic pretreatment given for…
Model: Single-dose total body gamma irradiation, 6.5 Gy at 1.0 Gy/min using a Gammacell 40 Exactor; 8 Gy total body irradiation for the faecal microbiota transplantation plus bone marrow transplant experiments
Faecal microbiota transplantation given by daily gavage for 10 days after 6.5 Gy total body irradiation significantly increased survival and body weight in both sexes, with best results when donor and recipient sex matched. It restored spleen size, raised peripheral white blood cell counts, increas…
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