Bezlotoxumab as First Option in Multiple Recurrent Clostridioides Difficile Infection (vs FMT)
Clostridium Infections · Enterocolitis, Pseudomembranous
Enrolment: 0 · Results not recorded
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Biologic · Live microbial consortium transfer plus microbial metabolites; not a ChEMBL drug entity, so unresolved. Trials listed are human faecal microbiota transplantation studies, none trauma-specific.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Clostridium Infections · Enterocolitis, Pseudomembranous
Enrolment: 0 · Results not recorded
Type 1 Diabetes
Enrolment: 20 · Results not recorded
Obesity
Enrolment: 24 · Results not recorded
Clostridium Difficile · Inflammatory Bowel Disease · Crohn's Disease · Ulcerative Colitis
Enrolment: 250 · Results not recorded
Steroid-Resistant Nephrotic Syndrome
Enrolment: 120 · Results not recorded
Infection Resistant to Drugs
Enrolment: 20 · Results not recorded
Clostridium Difficile Infection
Enrolment: 37 · Results not recorded
Irritable Bowel Syndrome With Diarrhea
Enrolment: 61 · Results not recorded
Irritable Bowel Syndrome
Enrolment: 35 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Acute radiation syndrome induced by single total body ionising radiation at 8.0 to 9.2 Gy (dose dependent on sex, age and specific pathogen-free or germ-free status); a separate tumour model used 10 Gy localised radiotherapy to subcutaneous B16F10 melanoma
Elite-survivor microbiota conferred radioprotection: about 75% of dirty cage recipients survived high dose total body radiation versus about 20% of control cage recipients, with lower clinical scores, reduced bone marrow caspase 3 and increased Ki67, and preserved splenic architecture. Lachnospirac…
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Model: Single-dose total body gamma irradiation, 6.5 Gy at 1.0 Gy/min using a Gammacell 40 Exactor; 8 Gy total body irradiation for the faecal microbiota transplantation plus bone marrow transplant experiments
Faecal microbiota transplantation given by daily gavage for 10 days after 6.5 Gy total body irradiation significantly increased survival and body weight in both sexes, with best results when donor and recipient sex matched. It restored spleen size, raised peripheral white blood cell counts, increas…
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