Diclofenac pretreatment modulates exercise-induced inflammation in skeletal muscle of rats through the TLR4/NF-kappaB pathway.
RatOtherWistarmalen = 20 rats in 4 groupsadministered for 7 days prior to the acute eccentric exercise bout
Model: Acute eccentric exercise bout inducing skeletal muscle inflammation
Diclofenac pretreatment attenuated the exercise-induced rise in COX-2, iNOS, IL-6, IL-1beta and TNF-alpha and blunted upregulation of TLR4, MyD88 and p65 in rat skeletal muscle.
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