Drug · Cyclooxygenase inhibitor (action type INHIBITOR; direct interaction, disease efficacy)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Postcraniotomy Headache · Postoperative Complications
Enrolment: 200 · Results not recorded
Pain
Enrolment: 196 · Results not recorded
Fever
Enrolment: 2 · Results not recorded
Osteoarthritis
Enrolment: 91 · Results not recorded
Chronic Low Back Pain
Enrolment: 401 · Results not recorded
Osteoarthritis
Enrolment: 1176 · Results not recorded
Osteoarthritis
Enrolment: 1164 · Results not recorded
Acute Pain
Enrolment: 214 · Results not recorded
Osteoarthritis, Knee
Enrolment: 750 · Results not recorded
Osteoarthritis of the Knee
Enrolment: 420 · Results not recorded
Otitis Externa
Enrolment: 20 · Results not recorded
Bioequivalence
Enrolment: 6 · Results not recorded
Interaction
Enrolment: 30 · Results not recorded
Neuralgia · Postherpetic Neuralgia · Complex Regional Pain Syndrome
Enrolment: 35 · Results not recorded
Sciatica Due to Intervertebral Disc Disorder
Enrolment: 324 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Carrageenan and croton oil acute oedema, increased vascular permeability, ultraviolet erythema, granulation tissue proliferation, and adjuvant arthritis
The cream base was the most effective vehicle and the 1.0 per cent preparation inhibited vascular permeability, acute oedema, ultraviolet erythema and adjuvant arthritis swelling, with activity comparable to indomethacin gel and greater than bufexamac cream and mobilat ointment. Effect on granulati…
Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.
Model: Acute eccentric exercise bout inducing skeletal muscle inflammation
Diclofenac pretreatment attenuated the exercise-induced rise in COX-2, iNOS, IL-6, IL-1beta and TNF-alpha and blunted upregulation of TLR4, MyD88 and p65 in rat skeletal muscle.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Acute subdural haematoma induced by subdural injection of 0.1 ml non-heparinised autologous tail vein blood
Diclofenac sodium given after acute subdural haematoma was associated with a further reduction in hippocampal neuron numbers in CA1, CA2 and CA3 and in total neuron number relative to untreated haematoma, together with necrotic areas, reduced c-FOS positivity, increased PGC-1alpha positivity and hi…
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Excisional full-thickness skin wound
Oral diclofenac lowered wound VEGF protein and impaired new blood vessel formation in acute wound tissue, consistent with reduced PGE2-triggered VEGF expression in wound keratinocytes.
Extraction: extract · Supplied extraction confidence: 0.35. Machine-extracted fields require source verification.
