Biliary tract external drainage protects against multiple organs injuries of severe acute pancreatitis rats via heme oxygenase-1 upregulation.
RatChemical/toxinSprague-Dawleyn = 30 rats, 6 per group across five groupsSurgical cannulation of the bile ductPerformed at the time of pancreatitis induction; tissue and blood collected 24…
Model: Severe acute pancreatitis induced by retrograde injection of 4% sodium taurocholate at 1 mL/kg into the biliopancreatic duct through the duodenal wall
Biliary tract external drainage significantly reduced organ damage and lowered serum amylase, ALT, AST, diamine oxidase, myeloperoxidase and lipopolysaccharide, increased the ability to inhibit hydroxyl radical, reduced tissue tumour necrosis factor alpha and interleukin 6 and increased haem oxygen…
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