Effect of Low-Dose Selenium Supplementation on the Genotoxicity, Tissue Injury and Survival of Mice Exposed to Acute Whole-Body Irradiation
MouseRadiationBALB/cMaleIntraperitoneal4 micrograms per kg body weightStarted 5 days before whole-body irradiation and continued after irradiation un…
Model: Acute whole-body irradiation at an absorbed dose of 8 Gy from a cobalt-60 source at 1 Gy/min
Low-dose sodium selenite did not protect against radiation-induced haematopoietic or gastrointestinal injury and did not improve 30-day survival, but it significantly prevented radiation-induced genotoxicity in peripheral leukocytes, differentially modulated GPx1, GPx2 and GPx4 mRNA in spleen and i…
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