Insulin treatment prevents wounding associated changes in tissue and circulating neutrophil MMP-9 and NGAL in diabetic rats
RatWoundSprague-DawleyMalen = Implant model: control n=25, diabetic n=35, insulin treated…Intensively treated group 10 IU/day; diabetic maintenance g…Started from onset of diabetes, one week after streptozotocin injection and app…
Model: Streptozotocin-induced diabetic rats subjected to full-thickness excisional skin wounds (four 8 mm biopsy punch wounds on the dorsum) and, in a parallel model, subcutaneous implantation of four sterile polyvinyl alcohol sponges via 1 cm dorsal incisions
Diabetes slowed healing (1.2 versus 1.62 mm/day in controls, P<0.05) and increased granulation tissue NGAL and MMP-9, implant neutrophil NGAL and MMP-9, wound fluid active MMP-9 and NGAL/MMP-9 complex, and circulating neutrophil NGAL, MMP-9 and MMP-8. Daily insulin from diabetes onset restored heal…
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