Vaginal estrogen: a dual-edged sword in postoperative healing of the vaginal wall
RatWoundSprague-DawleyFemalen = 170 rats in total; placebo n=41, oestrogen cream n=47, mese…Intravaginal cream application; mesenchymal stromal cells by direct injection into the subepithelial space of the injured posterior vaginal wall with a 19-gauge needle625 ng conjugated equine oestrogen per dose in 100 mg of cr…Cream started on the day of injury; cell or PBS injection given 3 to 4 days aft…
Model: Surgical injury of the posterior vaginal wall, an incision from the introitus to the cervix through epithelium and stroma, performed two weeks after bilateral ovariectomy as a menopausal model
Mesenchymal stromal cells did not survive beyond about one week, were absent by three weeks, and had no effect on biomechanics, collagen content or histology whether given alone or with oestrogen. Postoperative vaginal oestrogen produced a more profound loss of stiffness, greater loss of total coll…
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