THERAPY DOSSIER · th-c5be6c03b47f

Conjugated equine oestrogen vaginal cream, alone or combined with injected rat bone marrow-derived mesenchymal stromal cells

Hormone · Estrogen receptor agonist (AGONIST)

Evidence & regulatory context

Mechanism: Estrogen receptor agonist (AGONIST)
Target: CHEMBL2093866
Injury models: Wound
Reported indication: Not recorded
First approval: 1942
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Conjugated estrogens; Estrogens, conjugated; Oestrogens conjugated; Premarin; G03CA57
Note: Not recorded

Clinical trials 10

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01778985 ↗PHASE4completed

Effect of Preoperative Estrogen (Premarin) on Connective Tissues of the Pelvic Floor

Pelvic Organ Prolapse · Menopause

Enrolment: 30 · Results not recorded

NCT02835846 ↗PHASE4completed

Effect of the Female Urinary Microbiome on Incontinence (Estrogen Cream)

Overactive Bladder · Incontinence · Nocturia

Enrolment: 35 · Results not recorded

NCT02213757 ↗PHASE4terminated

Vaginal Estrogen (Premarin cream) on Asymptomatic Microhematuria RCT [EVER Study]

Microscopic Hematuria

Enrolment: 29 · Results not recorded

NCT02431897 ↗PHASE4completed

Minimize Prolapse Recurrence Using Conjugated Estrogens Cream

Pelvic Organ Prolapse · Urogenital Prolapse · Vaginal Vault Prolapse · Cystocele · Uterine Prolapse

Enrolment: 206 · Results not recorded

NCT02869165 ↗PHASE4completed

Vaginal Estrogen (Conjugated Equine Estrogen cream) and Nonhormonal Alternative on Microbiome in GSM

Atrophic Vaginitis · Menopause · Recurrent Urinary Tract Infections

Enrolment: 110 · Results not recorded

NCT07030426 ↗PHASE3recruiting

Vaginal Estrogen for Improvement of Outcomes Following Pelvic Organ Prolapse Surgery

Pelvic Organ Prolapse (POP)

Enrolment: 180 · Results not recorded

NCT05118685 ↗PHASE1unknown

Vaginal Oestrogen Cream vs Platelet Rich Plasma in Atrophic Vaginitis

Atrophic Vaginitis · Postmenopausal Atrophic Vaginitis

Enrolment: 100 · Results not recorded

NCT04301934 ↗NAcompleted

Fractional CO2 Vaginal LASER Therapy for Recurrent UTI (arms incl. conjugated estrogen)

Urinary Tract Infections

Enrolment: 12 · Results not recorded

NCT02691936 ↗NAcompleted

Vaginal Laser Therapy vs Vaginal Estrogen (Conjugated Estrogens USP) in GSM

Atrophic Vaginitis · Menopause

Enrolment: 69 · Results not recorded

NCT05464654 ↗NAcompleted

VABIP Study (Polydeoxyribonucleotides) vs Conjugated Estrogens Cream for GSM

Genitourinary Syndrome of Menopause · Postmenopausal Disorder · Menopause · Vagina Atrophy

Enrolment: 136 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28169915 ↗2017Mixed findings

Vaginal estrogen: a dual-edged sword in postoperative healing of the vaginal wall

RatWoundSprague-DawleyFemalen = 170 rats in total; placebo n=41, oestrogen cream n=47, mese…Intravaginal cream application; mesenchymal stromal cells by direct injection into the subepithelial space of the injured posterior vaginal wall with a 19-gauge needle625 ng conjugated equine oestrogen per dose in 100 mg of cr…Cream started on the day of injury; cell or PBS injection given 3 to 4 days aft…

Model: Surgical injury of the posterior vaginal wall, an incision from the introitus to the cervix through epithelium and stroma, performed two weeks after bilateral ovariectomy as a menopausal model

Mesenchymal stromal cells did not survive beyond about one week, were absent by three weeks, and had no effect on biomechanics, collagen content or histology whether given alone or with oestrogen. Postoperative vaginal oestrogen produced a more profound loss of stiffness, greater loss of total coll…

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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