Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype
MouseIschaemia-reperfusionCardiacC57BL (from MeSH indexing)Female (from MeSH indexing)
Model: Myocardial infarction induced by coronary artery ligation in neutrophil-depleted mice
Neutrophil depletion after myocardial infarction worsened cardiac function, increased fibrosis and led to progressive heart failure, with fewer Ly6C-high monocytes, more macrophages, reduced M1 and increased M2 markers, reduced MerTK expression and more TUNEL-positive cells in the infarct. Administ…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.