THERAPY DOSSIER · th-ca49a577694a

Neutrophil secretome and neutrophil gelatinase-associated lipocalin (NGAL, lipocalin-2)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28158426 ↗2017Reported benefit

Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype

MouseIschaemia-reperfusionCardiacC57BL (from MeSH indexing)Female (from MeSH indexing)

Model: Myocardial infarction induced by coronary artery ligation in neutrophil-depleted mice

Neutrophil depletion after myocardial infarction worsened cardiac function, increased fibrosis and led to progressive heart failure, with fewer Ly6C-high monocytes, more macrophages, reduced M1 and increased M2 markers, reduced MerTK expression and more TUNEL-positive cells in the infarct. Administ…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.

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