Neuroprotective effects of dexmedetomidine against hyperoxia-induced injury in the developing rat brain
RatOtherWistarmale and femalen = 10 pups per group across 8 groups, with 5 per group used fo…Intraperitoneal injection, given at a fixed proportion of body weight (100 microlitres per 10 g)1, 5 or 10 micrograms/kg body weightSingle pretreatment 15 min before the start of oxygen exposure
Model: Hyperoxia-induced injury of the developing brain, with exposure to 80% oxygen or room air for 24 h in neonatal rats
Hyperoxia sharply reduced proliferation (PCNA), neuronal markers (Nestin, PSA-NCAM, NeuN), the transcription factors SOX2, Tbr2 and Prox1, and the plasticity factors Nrp1, Nrg1, Syp, Sema3a and Sema3f at both mRNA and protein level. A single pretreatment with dexmedetomidine largely reversed these…
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