Human umbilical cord-derived mesenchymal stromal cells protect against premature renal senescence resulting from oxidative stress in rats with acute kidney injury.
RatIschaemia-reperfusionRenalWistar-KyotoMalen = Control group n = 4, ischaemia-reperfusion group n = 9, isc…Intraperitoneal, in 2 mL saline6 h after reperfusion
Model: Bilateral renal artery clamping for 45 min followed by reperfusion
Human umbilical cord-derived mesenchymal stromal cells given 6 h after reperfusion improved glomerular filtration and tubular function, restored AQP2, Klotho and MnSOD, reduced senescence markers and macrophage infiltration, and lessened renal fibrosis at day 49. Adipose-derived cells were protecti…
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