THERAPY DOSSIER · th-c5438dbe27a4

Human umbilical cord (Wharton's jelly)-derived mesenchymal stromal cells, passages P3 to P5, with human adipose-derived mesenchymal stromal cells as comparator

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 7

3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01873547 ↗Injury indicationPHASE3completed

Different Efficacy Between Rehabilitation Therapy and Umbilical Cord Derived Mesenchymal Stem Cells Transplantation in Patients With Chronic Spinal Cord Injury in China

Spinal Cord Injury

Enrolment: 300 · Results not recorded

NCT06981338 ↗Injury indicationPHASE1/PHASE2not yet recruiting

Guttmann NeuroRecovery - Viability, Safety and Efficacy of Intrathecal Wharton's Jelly Mesenchymal Stem Cells and Transcutaneous Spinal Cord Stimulation in Chronic Spinal Cord Injury Rehabilitation: A Pilot Study

Traumatic Spinal Cord Injuries · Spinal Cord Injury

Enrolment: 10 · Results not recorded

NCT02981576 ↗Injury indicationPHASE1/PHASE2completed

Comparative Evaluation of Safety and Effectiveness of Autologous Bone Marrow Derived Mesenchymal Stem Cells (BM-MSC) vs Adipose Tissue Derived Mesenchymal Stem Cells (AT-MSC) in the Treatment of Spinal Cord Injury Patients

Spinal Cord Injuries

Enrolment: 14 · Results not recorded

NCT02378974 ↗PHASE1/PHASE2completed

A Randomized, Double-blind, Placebo-controlled Phase I/IIa Trial of Intravenous Human Umbilical Cord-derived Mesenchymal Stem Cells in Patients With Cerebral Infarction

Cerebral Infarction

Enrolment: 18 · Results not recorded

NCT01218464 ↗PHASE1/PHASE2unknown

Phase I/II Study of Human Umbilical Cord Derived Mesenchymal Stem Cells (UC-MSCs) for Treatment of Liver Failure

Liver Failure

Enrolment: 70 · Results not recorded

NCT01207869 ↗PHASE1unknown

Intratracheal Instillation of Umbilical Cord-derived Mesenchymal Stem Cells as a Rescue Treatment for Severe Bronchopulmonary Dysplasia

Bronchopulmonary Dysplasia

Enrolment: 10 · Results not recorded

NCT05984303 ↗PHASE1unknown

Treatment of Decompensated Cirrhosis Using Human Umbilical Cord-derived Mesenchymal Stem Cells: A Phase 1, Multiple Administration, Dose-escalation Trial

Decompensated Cirrhosis

Enrolment: 6 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28129785 ↗2017Reported benefit

Human umbilical cord-derived mesenchymal stromal cells protect against premature renal senescence resulting from oxidative stress in rats with acute kidney injury.

RatIschaemia-reperfusionRenalWistar-KyotoMalen = Control group n = 4, ischaemia-reperfusion group n = 9, isc…Intraperitoneal, in 2 mL saline6 h after reperfusion

Model: Bilateral renal artery clamping for 45 min followed by reperfusion

Human umbilical cord-derived mesenchymal stromal cells given 6 h after reperfusion improved glomerular filtration and tubular function, restored AQP2, Klotho and MnSOD, reduced senescence markers and macrophage infiltration, and lessened renal fibrosis at day 49. Adipose-derived cells were protecti…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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