Effect of mesenchymal stem cells on small intestinal injury in a rat model of acute necrotizing pancreatitis.
RatChemical/toxinSprague-DawleyMalen = 120 rats randomised to four groups of 30, with n = 10 per g…Tail vein (intravenous), 1 mL per doseFirst dose immediately after model induction, at the moment the abdomen was clo…
Model: Acute necrotizing pancreatitis induced by retrograde biliopancreatic duct infusion of 5% sodium taurocholate, 0.1 mL per 100 g body weight at 0.04 mL/min, with clamps released after 10 min
Intravenous mesenchymal stem cells reduced serum and ascites amylase, ascites output and ascitic albumin, raised serum albumin and lessened pancreatic histological damage. They also reduced small intestinal capillary leakage and endothelial gap formation and reversed the fall in intestinal aquapori…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.