Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Chemical/toxin
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 4
4 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Comparative Evaluation of Safety and Effectiveness of Autologous Bone Marrow Derived Mesenchymal Stem Cells (BM-MSC) vs Adipose Tissue Derived Mesenchymal Stem Cells (AT-MSC) in the Treatment of Spinal Cord Injury Patients
Spinal Cord Injuries
Enrolment: 14 · Results not recorded
Phase I/II Trial of Autologous Bone Marrow Derived Mesenchymal Stem Cells to Patients With Spinal Cord Injury
Spinal Cord Injury
Enrolment: 20 · Results not recorded
Phase I, Single Center Trial to Assess Safety and Tolerability of Intrathecal Infusion of Ex-vivo Expanded Bone-marrow Derived Mesenchymal Stem Cells for the Treatment of Spinal Cord Injury
Spinal Cord Injury
Enrolment: 10 · Results not recorded
Assessment of Safety and Effectiveness of Mesenchymal Stem Cells in the Treatment of Spinal Cord Injury Patients
Spinal Cord Injuries
Enrolment: 20 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatChemical/toxinSprague-DawleyMalen = 120 rats randomised to four groups of 30, with n = 10 per g…Tail vein (intravenous), 1 mL per doseFirst dose immediately after model induction, at the moment the abdomen was clo…
Model: Acute necrotizing pancreatitis induced by retrograde biliopancreatic duct infusion of 5% sodium taurocholate, 0.1 mL per 100 g body weight at 0.04 mL/min, with clamps released after 10 min
Intravenous mesenchymal stem cells reduced serum and ascites amylase, ascites output and ascitic albumin, raised serum albumin and lessened pancreatic histological damage. They also reduced small intestinal capillary leakage and endothelial gap formation and reversed the fall in intestinal aquapori…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
