Nephroprotective Effects of N-Acetylcysteine Amide against Contrast-Induced Nephropathy through Upregulating Thioredoxin-1, Inhibiting ASK1/p38MAPK Pathway, and Suppressing Oxidative Stress and Apoptosis in Rats.
RatChemical/toxinSprague-DawleyMalen = 40 rats total, 8 per group across 5 groupsIntraperitonealNACA 50 mg/kg/day or 150 mg/kg/day; comparator NAC 150 mg/k…Pretreatment; dosing began 3 days before contrast media injection and continued…
Model: Contrast-induced nephropathy induced by 24 h dehydration followed by L-NAME (10 mg/kg i.p.), indomethacin (10 mg/kg i.p.) and iohexol (1.5 to 2 g iodine/kg i.p.)
NACA attenuated rises in serum creatinine, blood urea nitrogen and tubular injury biomarkers, reduced histological and ultrastructural tubular damage, lowered TUNEL-positive cells and cleaved caspase 3, preserved SOD and GSH while lowering MDA, and reversed contrast-induced Trx1 downregulation and…
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