24-Month Trial of NPI-001 for Preservation of Photoreceptors in Retinitis Pigmentosa Associated With Usher Syndrome
Retinitis Pigmentosa · Usher Syndrome
Enrolment: 80 · Results not recorded
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Drug
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Retinitis Pigmentosa · Usher Syndrome
Enrolment: 80 · Results not recorded
Cystinosis
Enrolment: 12 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Contrast-induced nephropathy induced by 24 h dehydration followed by L-NAME (10 mg/kg i.p.), indomethacin (10 mg/kg i.p.) and iohexol (1.5 to 2 g iodine/kg i.p.)
NACA attenuated rises in serum creatinine, blood urea nitrogen and tubular injury biomarkers, reduced histological and ultrastructural tubular damage, lowered TUNEL-positive cells and cleaved caspase 3, preserved SOD and GSH while lowering MDA, and reversed contrast-induced Trx1 downregulation and…
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
Model: Upper lumbar contusion spinal cord injury
NACA improved mitochondrial bioenergetics dose-dependently with maximum effect at 300 mg/kg, maintained mitochondrial glutathione near normal, and one week of delivery improved hindlimb function and increased tissue sparing.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.