Daily propranolol administration reduces persistent injury-associated anemia after severe trauma and chronic stress.
RatHaemorrhage/shockControlledSprague-DawleyMalen = 8 per group across 5 groups (40 rats)Intraperitoneal10 mg/kgFirst dose 10 minutes after lung contusion and haemorrhagic shock; in chronic s…
Model: Unilateral lung contusion by percussive nail gun followed by haemorrhagic shock (mean arterial pressure 30 to 35 mmHg for 45 min with reinfusion of shed blood), with or without daily 2 h restraint chronic stress for six days
Daily propranolol after lung contusion, haemorrhagic shock and chronic stress raised haemoglobin by about 20 per cent (13.7 plus or minus 0.4 versus 10.8 plus or minus 0.8 g/dL), restored bone marrow cellularity to naive levels, improved CFU-GEMM, BFU-E and CFU-E colony growth by 9 to 39 per cent,…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.