Endoplasmic Reticulum Stress Modulation as a Target for Ameliorating Effects of Blast Induced Traumatic Brain Injury.
RatTBIBlast / overpressureSprague-Dawley1 mg/kgPost-blast
Model: Blast traumatic brain injury at 50 psi
Blast injury increased p-PERK and p-eIF2alpha at 30 min, p-T205 tau at 6 h and iron at 24 h in the left cortex, with behavioural changes on the Forced Swim Test at 72 h, Elevated Plus Maze at 7 days and learning disruption on the Morris Water Maze at 21 days. Salubrinal reduced ER stress markers in…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.