Spinal neuropeptide expression and neuropathic behavior in the acute and chronic phases after spinal cord injury: Effects of progesterone administration.
RatSpinal cord injuryHemisection / partialMaleSubcutaneousEarly treatment started after injury and sustained
Model: Spinal cord hemisection at the T13 level
Hemisection increased Y1R and Y2R and reduced GalR2 mRNA at 1 day, and increased galanin, NPY, GalR1 and Y1R at 28 days alongside established mechanical and cold allodynia. Early and sustained progesterone prevented Y1R upregulation acutely, normalised galanin, NPY, GalR1 and Y1R chronically, reduc…
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