Role of the NLRP3 inflammasome in a model of acute burn-induced pain.
MouseBurnContact / flameNlrp3-deficient, caspase-1-deficient (Ice) and wild-type miceMale
Model: Superficial burn to the plantar surface of the left hind paw using a hot plate at 52.5 degrees C for 25 s
Burn-induced mechanical and thermal allodynia developed normally in Nlrp3-deficient and caspase-1-deficient mice and in mice given MCC950. Oedema was reduced only in caspase-1-deficient mice, and weight bearing changes were attenuated in Nlrp3-deficient and MCC950-treated mice at 72 h only. The aut…
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