L-carnitine reduces susceptibility to bupivacaine-induced cardiotoxicity: an experimental study in rats.
RatChemical/toxinSprague-DawleyMalen = Experiment 1: n = 10 per group, 2 groups. Experiment 2: n =…Intravenous100 mg/kgExperiment 1: administered before the bupivacaine infusion. Experiment 2: admin…
Model: Bupivacaine-induced cardiotoxicity in anaesthetised, mechanically ventilated rats; experiment 1 used a bupivacaine infusion at 2.0 mg/kg/min until asystole, experiment 2 used a bolus of bupivacaine 20 mg/kg intravenously over 20 seconds to produce cardiac arrest
Pretreatment with L-carnitine 100 mg/kg increased the probability of survival during bupivacaine infusion (hazard ratio 12.0, 95% CI 3.5 to 41.5, P < 0.001) and prolonged time to asystole by 33%, first dysrhythmia by 65%, and 50% reductions in heart rate and mean arterial pressure by 71% and 63% re…
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