Levocarnitine + Vitamin B for PEG-Asparaginase/Inotuzumab Hyperbilirubinemia in ALL
Acute Lymphoblastic Leukemia · Hyperbilirubinemia
Enrolment: 10 · Results posted
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Nutraceutical
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Acute Lymphoblastic Leukemia · Hyperbilirubinemia
Enrolment: 10 · Results posted
Non Alcoholic Fatty Liver Disease
Enrolment: 60 · Results not recorded
End Stage Renal Disease · Insulin Resistance
Enrolment: 35 · Results not recorded
Non-Alcoholic Fatty Liver Disease · Insulin Resistance
Enrolment: 30 · Results not recorded
5 studies reported at therapy level; 5 evidence entries itemised.
Model: Bupivacaine-induced cardiotoxicity in anaesthetised, mechanically ventilated rats; experiment 1 used a bupivacaine infusion at 2.0 mg/kg/min until asystole, experiment 2 used a bolus of bupivacaine 20 mg/kg intravenously over 20 seconds to produce cardiac arrest
Pretreatment with L-carnitine 100 mg/kg increased the probability of survival during bupivacaine infusion (hazard ratio 12.0, 95% CI 3.5 to 41.5, P < 0.001) and prolonged time to asystole by 33%, first dysrhythmia by 65%, and 50% reductions in heart rate and mean arterial pressure by 71% and 63% re…
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Model: Single 20 Gy whole-abdomen irradiation causing acute ovarian damage
Irradiation reduced antral follicles and corpora lutea and raised malondialdehyde and advanced oxidation protein products. L-carnitine increased both antral follicle and corpus luteum counts, whereas amifostine improved corpus luteum counts only. Both agents significantly reduced malondialdehyde an…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Carboplatin-induced renal tubular injury (single intraperitoneal carboplatin 75 mg/kg in vivo; 200 µM carboplatin challenge in renal tubular cells in vitro)
L-carnitine markedly reduced carboplatin-induced renal injury. Histological damage was milder, carboplatin-induced renal tubular cell apoptosis was inhibited by approximately 75%, and the carboplatin-induced rises in serum urea nitrogen and creatinine were significantly alleviated. Protection depen…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
Model: Acute cardiotoxicity induced by a single intraperitoneal dose of cyclophosphamide 200 mg/kg or by ifosfamide 50 mg/kg per day intraperitoneally for 5 days
Cyclophosphamide and ifosfamide reduced cardiac heart fatty acid binding protein and carnitine palmitoyltransferase I expression and raised lactate dehydrogenase, creatine kinase MB and malonyl-CoA with histopathological lesions; carnitine supplementation reversed all biochemical, histopathological…
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Radiation-induced acute small intestinal injury after a single 20 Gy dose to the total abdomen
Amifostine reduced radiation-induced acute degenerative damage (P = 0.009) and lowered the overall damage score (P = 0.009) versus irradiation alone, whereas L-carnitine produced no significant difference in degenerative damage or overall score. Vascular damage was significantly reduced by both ami…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.