Apocynin suppressed the nuclear factor-kappaB pathway and attenuated lung injury in a rat hemorrhagic shock model.
RatHaemorrhage/shockControlledSprague-DawleyMalen = Sham n = 5; haemorrhagic shock n = 10; low-dose apocynin n…Intraperitoneal20 mg/kg (low dose) or 40 mg/kg (high dose)Administered at resuscitation, after the 40-minute shock period
Model: Controlled haemorrhagic shock with blood withdrawal to maintain mean arterial pressure at 20-25 mm Hg for 40 minutes, followed by resuscitation with the shed blood
Survival was 100% (5/5) in sham, 30% (3/10) in haemorrhagic shock, 40% (4/10) with low-dose apocynin and 70% (7/10) with high-dose apocynin. High-dose apocynin reduced gp91-phox expression, Nox activity, malondialdehyde, phosphorylated IkappaB-alpha, NF-kappaB p65 DNA binding, TNF-alpha and IL-6 ex…
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