A Placebo-controlled, Double-blinded, Randomized, Trial Using a Combination of Apocynin and Paeonol (APPA) for the Treatment of Knee Osteoarthritis
Osteoarthritis
Enrolment: 152 · Results not recorded
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Drug · No mechanism_of_action record in ChEMBL for CHEMBL346919. NADPH oxidase (NOX) inhibition is literature-reported, not asserted by the ChEMBL MoA table.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Osteoarthritis
Enrolment: 152 · Results not recorded
Chronic Obstructive Pulmonary Disease
Enrolment: 13 · Results not recorded
Cardiovascular Diseases · Cardiovascular Risk Factor · Vasodilation
Enrolment: 44 · Results not recorded
Cardiovascular Diseases · Cardiovascular Risk Factor · Vasoconstriction
Enrolment: 24 · Results not recorded
Cardiovascular Diseases · Cardiovascular Risk Factor · Vasoconstriction
Enrolment: 16 · Results not recorded
Bronchial Asthma
Enrolment: 10 · Results not recorded
Osteoarthritis
Enrolment: 40 · Results not recorded
Gestational Diabetes · Oxidative Stress
Enrolment: 40 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Moderate to severe contusion injury at T9 using the Ohio State University electromagnetic spinal cord injury device (0.5-0.6 cm displacement) after T8-T10 laminectomy; in vitro fluid percussion injury of astrocyte cultures (5 atmospheres, 25 ms, applied twice)
In vitro, apocynin at 10 and 100 microM reduced injured astrocyte media induced oligodendrocyte death from 61.5 +/- 6.02 per cent to 28.3 +/- 4.2 and 34.3 +/- 4.8 per cent, while 500 microM was ineffective; gp91 phox deficient oligodendrocytes were protected from injured astrocyte media and from 13…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.
Model: Controlled haemorrhagic shock with blood withdrawal to maintain mean arterial pressure at 20-25 mm Hg for 40 minutes, followed by resuscitation with the shed blood
Survival was 100% (5/5) in sham, 30% (3/10) in haemorrhagic shock, 40% (4/10) with low-dose apocynin and 70% (7/10) with high-dose apocynin. High-dose apocynin reduced gp91-phox expression, Nox activity, malondialdehyde, phosphorylated IkappaB-alpha, NF-kappaB p65 DNA binding, TNF-alpha and IL-6 ex…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Orthopaedic trauma (soft tissue and bone injury) causing acute kidney injury
Obese Zucker rats developed acute kidney injury after trauma with reduced glomerular filtration rate, raised plasma creatinine, urine kidney injury molecule-1 and albumin excretion, increased NADPH oxidase activity and lipid peroxidation, and suppressed superoxide dismutase. Apocynin significantly…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Severe hindlimb trauma by muscle injury, fibula fracture and bone component injection to both hindlimbs, causing acute lung injury
Obese rats showed greater increases in lung capillary filtration coefficient, neutrophil accumulation, NOX and myeloperoxidase activity and plasma IL-6 after trauma than lean rats. Apocynin reduced all of these measures and the wet to dry weight ratio in obese rats.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.