A Novel Mouse Model to Study Image-Guided, Radiation-Induced Intestinal Injury and Preclinical Screening of Radioprotectors.
MouseRadiationC57BL/6FemaleGiven daily both before and after irradiation
Model: Image-guided focal irradiation of the jejunum using a surgically implanted radiopaque fiducial marker, cone-beam CT targeting and the Small Animal Radiation Research Platform, delivering a 5 mm focal intestinal radiation field
Focal 5 mm intestinal irradiation produced acute reversible damage confined to the marked area, without weight loss or lethality, but with fibrosis and collagen deposition indicating chronic damage at 4 months. Curcumin-treated mice showed significant decreases in both local and systemic inflammato…
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