Acute cardiac support with intravenous milrinone promotes recovery from early brain injury in a murine model of severe subarachnoid haemorrhage.
MouseHaemorrhage/shockUnspecifiedC57BL/6Malen = 43 male C57BL/6 mice in total across all groupsIntravenous infusion0.25 to 0.75 micrograms/kg/minInfused between 1.5 and 2.5 hours after induction of subarachnoid haemorrhage
Model: Subarachnoid haemorrhage induced by endovascular perforation, with postconditioning using 2% isoflurane
Mild reduction in cardiac output and global depression of cerebral blood flow were seen early after subarachnoid haemorrhage. Milrinone increased cardiac output dose-dependently (P < 0.001) and improved hypoperfusion, incidence of delayed cerebral ischaemia and functional recovery compared with con…
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