10 Days IV Milrinone to Optimise Cerebral Haemodynamics and Prevent Delayed Cerebral Ischaemia in Severe Subarachnoid Haemorrhage
Aneurysmal Subarachnoid Hemorrhage
Enrolment: 234 · Results not recorded
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Drug · INHIBITOR of phosphodiesterase 3A (direct interaction, disease efficacy); ATC C01CE02, cardiac stimulant, phosphodiesterase inhibitor.
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Aneurysmal Subarachnoid Hemorrhage
Enrolment: 234 · Results not recorded
Vascular Spasm After Traumatic Subarachnoid Haemorrhage
Enrolment: 30 · Results not recorded
Cerebral Vasospasm
Enrolment: 4 · Results not recorded
Pulmonary Hypertension
Enrolment: 40 · Results not recorded
End Stage Heart Disease · Right Ventricular Dysfunction
Enrolment: 10 · Results not recorded
Cardiac Anaesthesia · Cardiopulmonary Bypass
Enrolment: 102 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Thoracic spinal cord contusion produced by weight-drop technique after laminectomy
Milrinone significantly improved neurological examination scores compared with untreated and saline-treated injury groups, reduced glutathione peroxidase, total oxidant status, 8-hydroxyguanosine and IL-6, raised IL-10 and total antioxidant status, and significantly lowered the histopathological sp…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Subarachnoid haemorrhage induced by endovascular perforation, with postconditioning using 2% isoflurane
Mild reduction in cardiac output and global depression of cerebral blood flow were seen early after subarachnoid haemorrhage. Milrinone increased cardiac output dose-dependently (P < 0.001) and improved hypoperfusion, incidence of delayed cerebral ischaemia and functional recovery compared with con…
Extraction: extract · Supplied extraction confidence: 0.82. Machine-extracted fields require source verification.