Histopathological and biochemical comparisons of the protective effects of amifostine and l-carnitine against radiation-induced acute testicular toxicity in rats.
RatRadiationWistar albinoMalen = 30 rats: control n = 6, amifostine plus radiotherapy n = 8,…IntraperitonealAmifostine 200 mg/kg; l-carnitine 300 mg/kg30 min before irradiation
Model: Single 20 Gy dose of radiotherapy delivered to the scrotal field, causing acute testicular damage
Both amifostine plus radiotherapy and l-carnitine plus radiotherapy groups had significantly greater mean seminiferous tubule diameters (p = 0.003 and p = 0.032) and significantly lower malondialdehyde (p < 0.004 and p < 0.012) than the irradiation-only group. The two agents had a similar radioprot…
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