Alginate Oligosaccharide Prevents Acute Doxorubicin Cardiotoxicity by Suppressing Oxidative Stress and Endoplasmic Reticulum-Mediated Apoptosis.
MouseChemical/toxinC57BL/6Malen = n = 6 per group in each of the two experimental parts (4 gr…Oral gavage200 mg/kg/day (2.0% solution in normal saline)Pretreatment arm: 7 consecutive days before doxorubicin, continued for a furthe…
Model: Acute doxorubicin cardiotoxicity induced by a single intraperitoneal injection of doxorubicin 15 mg/kg; a higher single dose of 20 mg/kg was used for survival experiments
Pretreatment was protective: at 20 mg/kg doxorubicin, 90% of untreated mice were dead by day 8 compared with 40% by day 15 with alginate oligosaccharide. Left ventricular end-systolic diameter increased 52% with doxorubicin and was markedly restored, and falls in ejection fraction (37%) and fractio…
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