Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Chemical/toxin
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 4
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
A Randomized Double-blind, Placebo-controlled Cross-over Study of Inhaled Alginate Oligosaccharide (OligoG) for 28 Days in Subjects With Cystic Fibrosis Using Aztreonam Due to Chronic Colonization With Burkholderia spp.
Cystic Fibrosis · Burkholderia Infection
Enrolment: 15 · Results not recorded
A Double-blind, Randomized, Placebo-controlled Cross Over Study of Inhaled Alginate Oligosaccharide (OligoG) Administered for 28 Days in Subjects With Cystic Fibrosis
Cystic Fibrosis
Enrolment: 65 · Results not recorded
A Phase 2b Randomised, Double-blind, Parallel-group Study of Alginate Oligosaccharide (OligoG) Dry Powder Inhalation in Addition to Standard of Care Compared to Placebo in Patients With Cystic Fibrosis
Cystic Fibrosis
Enrolment: 15 · Results not recorded
A Double-blind, Randomized, Placebo-controlled, Cross-over Study to Evaluate Safety, Tolerability and Preliminary Efficacy of Alginate Oligosaccharide (OligoG) Administered for 28 Days in Subjects With Cystic Fibrosis Chronically Colonised With Pseudomonas aeruginosa
Cystic Fibrosis
Enrolment: 26 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
MouseChemical/toxinC57BL/6Malen = n = 6 per group in each of the two experimental parts (4 gr…Oral gavage200 mg/kg/day (2.0% solution in normal saline)Pretreatment arm: 7 consecutive days before doxorubicin, continued for a furthe…
Model: Acute doxorubicin cardiotoxicity induced by a single intraperitoneal injection of doxorubicin 15 mg/kg; a higher single dose of 20 mg/kg was used for survival experiments
Pretreatment was protective: at 20 mg/kg doxorubicin, 90% of untreated mice were dead by day 8 compared with 40% by day 15 with alginate oligosaccharide. Left ventricular end-systolic diameter increased 52% with doxorubicin and was markedly restored, and falls in ejection fraction (37%) and fractio…
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