Anti-Inflammatory Effects of Rosiglitazone in Obesity-Impaired Wound Healing Depend on Adipocyte Differentiation.
MouseWoundC57Bl/6J-ob/ob (genetically obese) with wild-type C57Bl/6J as comparatorFemalen = Rosiglitazone wound analysis: wound tissue (three wounds pe…Oral gavage0.5 mg/kg/day, emulsified at 2 mg/mL in 0.5% TyloseTreatment started 2 days before wounding
Model: Six full-thickness excisional wounds, 5 mm in diameter and 3 to 4 mm apart, made on the back by excising skin and underlying panniculus carnosus under ketamine (80 mg/kg) and isoflurane anaesthesia
Oral rosiglitazone markedly improved the disturbed wound conditions in obese mice, giving complete re-epithelialisation and a collagen-enriched neo-dermis by day 13, a marked reduction in wound CXCL2 and cyclooxygenase-2 mRNA and protein, more regular subcutaneous adipocyte morphology, lower fastin…
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