TUDCA: An Agonist of the Bile Acid Receptor GPBAR1/TGR5 With Anti-Inflammatory Effects in Microglial Cells.
MixedOtherC57BL/6 mice and Wistar rats per MeSH indexing; strain not stated in the abstract
Model: Mouse model of acute neuroinflammation, with parallel in vitro microglial cell cultures; the inflammatory stimulus is not named in the abstract
TUDCA binding to GPBAR1/TGR5 increased intracellular cAMP in microglia, induced anti-inflammatory markers and reduced pro-inflammatory ones. The effect was blocked by small interfering RNA against GPBAR1/TGR5 and by a protein kinase A inhibitor. In the mouse model of acute neuroinflammation TUDCA t…
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