Modulating the Biologic Activity of Mesenteric Lymph after Traumatic Shock Decreases Systemic Inflammation and End Organ Injury.
Model: Trauma with haemorrhagic shock in rats: laparotomy with right medial visceral rotation, blood withdrawn from a femoral vein catheter until mean arterial pressure fell to 35 mmHg and held for 60 min, then resuscitation with shed blood plus twice the shed blood volume in normal saline over 2 h. Mesenteric lymph was collected during shock and infused into naive mice at 1 mL/kg/h for 3 h
Lymph from trauma with haemorrhagic shock caused hypotension and acute lung injury in naive mice. CPSI-121 treatment of the donor attenuated this: mean arterial pressure 66 to 73 mmHg versus 52 to 55 mmHg, monocyte pSTAT3 fold change 1.44 plus or minus 0.31 versus 2.3 plus or minus 0.47, lung injur…
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