Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Haemorrhage/shock · Burn
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 3
3 studies reported at therapy level; 3 evidence entries itemised.
MixedHaemorrhage/shockControlledSprague-Dawley rats; C57BL/6 miceMalen = n = 4 per group for donor rats and for recipient mice; n =…Intravenous1 mg/kgImmediately after induction of trauma with haemorrhagic shock
Model: Trauma with haemorrhagic shock in rats: laparotomy with right medial visceral rotation, blood withdrawn from a femoral vein catheter until mean arterial pressure fell to 35 mmHg and held for 60 min, then resuscitation with shed blood plus twice the shed blood volume in normal saline over 2 h. Mesenteric lymph was collected during shock and infused into naive mice at 1 mL/kg/h for 3 h
Lymph from trauma with haemorrhagic shock caused hypotension and acute lung injury in naive mice. CPSI-121 treatment of the donor attenuated this: mean arterial pressure 66 to 73 mmHg versus 52 to 55 mmHg, monocyte pSTAT3 fold change 1.44 plus or minus 0.31 versus 2.3 plus or minus 0.47, lung injur…
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RatHaemorrhage/shockControlledSprague-DawleyMaleIntravenous1 mg/kgGiven after the haemorrhagic shock phase in the trauma/haemorrhagic shock cohort
Model: Laparotomy plus 60 minutes of haemorrhagic shock (mean arterial pressure 35 mm Hg) followed by fluid resuscitation; sham controls
CPSI-121 increased efferent vagal discharge without altering blood pressure, prevented trauma and haemorrhagic shock induced gut and lung injury, and attenuated mesenteric lymph mediated neutrophil priming.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
MouseBurnUnspecifiedBALB/c (Jackson Laboratories)MaleIntravenous tail vein injection1 mg/kg diluted in 150 microlitre sterile water; vagus nerv…Immediately after the burn, with assessment at 4 hours
Model: Full-thickness 30% total body surface area dorsal steam burn applied for 7 seconds under inhaled isoflurane, with subcutaneous saline and buprenorphine resuscitation
CPSI-121 significantly reduced 4-kDa FITC-dextran permeability and preserved normal ileal histology and ZO-1 and occludin expression after burn, comparably to vagus nerve stimulation; abdominal vagotomy abolished the protection while splenectomy did not.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
