Regulation of Mitochondrial Function and Glutamatergic System Are the Target of Guanosine Effect in Traumatic Brain Injury.

Regulation of Mitochondrial Function and Glutamatergic System Are the Target of Guanosine Effect in Traumatic Brain Injury.

Model: Unilateral moderate fluid percussion brain injury

Fluid percussion injury caused mitochondrial dysfunction and reduced glutamate uptake and glial glutamate transporter levels, and guanosine ameliorated both the mitochondrial damage and the glutamatergic dyshomeostasis.

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