Effect of TREM-1 blockade and single nucleotide variants in experimental renal injury and kidney transplantation.
MouseIschaemia-reperfusionRenalC57BL/6 wild type, pathogen freeMalen = Murine group sizes not stated; human cohort 1263 donor-reci…IntraperitonealFusion protein 1, 2.5 and 5 micrograms in 100 microlitres;…Fusion protein and LP17 one hour before surgery; LR12 starting two hours before…
Model: Renal ischaemia-reperfusion with renal pedicles clamped for 25 minutes uni- or bilaterally under isoflurane anaesthesia and sacrifice 24 hours after reperfusion; sham underwent the same surgery without clamping
All three TREM-1 inhibitors partially downregulated inflammatory transcripts but did not prevent renal damage, leukocyte influx or organ dysfunction, and TREM1 p.Thr25Ser variants were not associated with delayed graft function, rejection or graft failure.
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