THERAPY DOSSIER · th-f05fce1d064f

TREM-1 inhibitors LP17 peptide, LR12 peptide and a TREM-1 fusion protein

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03158948 ↗PHASE2completed

Safety, tolerability, PK and PD of three doses of MOTREM (nangibotide) in septic shock

Septic Shock

Enrolment: 50 · Results not recorded

NCT04429334 ↗PHASE2completed

Nangibotide in COVID-19 patients with ventilatory support (ESSENTIAL)

COVID-19

Enrolment: 220 · Results not recorded

NCT03463044 ↗PHASE1completed

Phase I ascending single IV doses of MOTREM (LR12) in healthy male subjects

Healthy Subjects

Enrolment: 27 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27928159 ↗2016No effect reported

Effect of TREM-1 blockade and single nucleotide variants in experimental renal injury and kidney transplantation.

MouseIschaemia-reperfusionRenalC57BL/6 wild type, pathogen freeMalen = Murine group sizes not stated; human cohort 1263 donor-reci…IntraperitonealFusion protein 1, 2.5 and 5 micrograms in 100 microlitres;…Fusion protein and LP17 one hour before surgery; LR12 starting two hours before…

Model: Renal ischaemia-reperfusion with renal pedicles clamped for 25 minutes uni- or bilaterally under isoflurane anaesthesia and sacrifice 24 hours after reperfusion; sham underwent the same surgery without clamping

All three TREM-1 inhibitors partially downregulated inflammatory transcripts but did not prevent renal damage, leukocyte influx or organ dysfunction, and TREM1 p.Thr25Ser variants were not associated with delayed graft function, rejection or graft failure.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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