The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate.
RatChemical/toxinMale (testicular study)n = 31 rats divided into 4 groups; per-group numbers not statedIntraperitoneal100 mg/kg vitamin C; vehicle 2 mL/kg saline; methotrexate 1…Two schedules compared, vitamin C before methotrexate and vitamin C after metho…
Model: Methotrexate-induced testicular injury with methotrexate 10 mg/kg/day intraperitoneally
Vitamin C reduced methotrexate-induced testicular histological injury, with significantly better tubular diameter, germinal epithelial thickness and biopsy score when given before rather than after methotrexate.
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